Lipid Rafts and Bullous Diseases

Lipid Rafts and Bullous Diseases

Multiple observations point to involvement of lipid membrane domains, known as lipid rafts, in the pathology of human disorders. The putative role of lipid rafts in hereditary and acquired skin blistering diseases is discussed in this review. Stable adhesion of the epidermis to the underlying basement membrane is secured by hemidesmosomes, specialized multiprotein complexes in basal keratinocyt...

Targeting Lipid Rafts, Seeking Cures for Diseases

The components and ratio of lipids species assembled into biomembrane is another essential factor contributing to the specific behaviors of lipid rafts. From two lipid metabolism genes mutation models, we understood that the nature of biomembrane are very different between mammals and Drosophila. NeutralCeramidase (N-CDase) nude mice do not have significant phenotype, even the N-CDase nude MEFs...

Lipid rafts , cholesterol and apoptosis in cancer and neurodegenerative diseases

The dynamic nature of membrane along with an uneven distribution of lipids leads to the formation of specialized membrane domains where proteins can selectively be included or excluded. In this regard, the dynamic and preferential clustering and packing of sphingolipids and cholesterol into moving platforms, named as lipid rafts, form membrane domains that act as scaffolds for the attachment of...

Cholesterol, lipid rafts, and disease.

Lipid rafts and insulin signaling.

Lipid rafts are domains within the plasma membrane that are enriched in cholesterol and lipids with saturated acyl chains. Specific proteins, including many signaling proteins, segregate into lipid rafts, and this process is important for certain signal transduction events in a variety of cell types. Within the past decade, data have emerged from many laboratories that implicate lipid rafts as ...